A high-fat diet in mice prevents the eggs from becoming healthy embryos, a finding that may explain infertility problems in obese women.Researchers at the University of Adelaide in Australia discovered that the main cause of diet-induced infertility in mice is a protein which can be found in cells that nourish eggs."The behavior of this protein helps to determine the way in which the ovaries sense and respond to fats," said researcher Cadence Minge. "Being able to control this protein will be very important in the quest to reverse fertility caused by poor diets."Minge et al proved that the anti-diabetes drug rosglitazone helped counter the effects of this protein in mice, resulting in better rates of fetal survival and higher birth weights.However, due to potential side effects, applying this drug in infertile obese women yet needs more studies.So far "weight loss" is the most effective way for obese women to restore fertility.